Expression and clinical significance of CD38 and CD133 in myelodysplastic syndrome

VernacularTitle:CD38、CD133抗原在骨髓增生异常综合征中的表达及临床意义
Author: Lidong ZHAO ; Lianguo XUE ; Ying WANG ; Jin YANG ; Mingqing ZHU ; Shaolin ZHAO
Publication Type:Journal Article
Keywords: Myelodysplastic syndrome; Immunophenotyping; Flow cytometry
From: Clinical Medicine of China 2010;26(5):479-481
CountryChina
Language:Chinese
Abstract: Objective Analysis of the expression of CD38,CD133 antigen and their clinical significance in myelodysplastic syndrome (MDS).Methods CD38 and CD133 antigen were analyzed by flow cytometry in 31 cases of MDS patients.Results CD38 was expressed in 18 cases (58.1% ),among them,12 cases were found to be myelodysplastic syndrome refractoryanermia ( MDS-RA ),accounting for 57.1%,6 cases were found to be MDS-RAEB,accounting for 66.7%.CD133 was expressed in 20 cases(64.5% ) ,among them,11 cases were found to be MDS-RA ( 52.4% ),1 case MDS-RAS,and 8 cases of MDS-RAEB,accounting for 88.9% .CD38 expressed significantly higher in MDS than anemia and relatively normal group ( P ＜ 0.05 ).CD133 expression in anemia groups was different from MDS-RA without statistical significance ( P ＞ 0.05 ),but was significantly different from relatively normal group (P ＜0.05).CD133 expression was significantly higher in these with MDS-RAEB than those in anemia and normal group ( P ＜ 0.05 ).Conclusions Combining with conventional antibodies,flow cytometry used in detection of CD38 ,CD133 ,could improve the diagnostic rate of MDS.