Inhibiting NF-κB activity down-regulates angiotensinogen expression level in cultured rat mesangial cells
10.3760/cma.j.issn.1000-6699.2010.05.019
- VernacularTitle:抑制NF-κB活性下调高糖培养的大鼠肾小球系膜细胞血管紧张素原表达水平
- Author:
Jin LI
;
Ying GUO
;
Bin HUANG
;
Helin DING
;
Zuzhi FU
- Publication Type:Journal Article
- Keywords:
Mesangial cells;
NF-kB;
Angiotensinogen;
Angiotensin Ⅱ
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(5):411-412
- CountryChina
- Language:Chinese
-
Abstract:
The angiotensinogen(AGT) expression and angiotensin Ⅱ (AngⅡ ) secretion levels in cultured SD rat mesangial cells were determined. High glucose up-regulated AGT mRNA(0. 29±0.07 vs 0. 20±0. 05,P< 0.05)and protein(0.66±0.23 vs 0.37±0. 15,P<0.05) expression and Ang Ⅱ secretion [(9.85±2.08 vs 7.50± 1. 51) pg/ml,P<0. 05]levels, which were down-regulated by pyrrolidine dithiocarbamate( PDTC) treatment via inhibiting NF-κB activity.
