Comparison on the clinic features and neuromyelitis optica-IgG positive rate of neuromyelitis optica and multiple sclerosis
10.3760/cma.j.issn.1006-7876.2010.06.013
- VernacularTitle:视神经脊髓炎与多发性硬化的临床表现和视神经脊髓炎IgG抗体阳性率的对比
- Author:
Hai YU
;
Yuqiao LI
;
Jiahong LU
;
Baoguo XIAO
;
Zhenxin LI
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Multiple sclerosis;
Aquaporin 4;
Immunoglobulin G
- From:
Chinese Journal of Neurology
2010;43(6):417-420
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinic features of neuromyelitis optica (NMO) and multiple sclerosis(MS).To compare the positive rate of NMO-IgG in NMO,MS and other related diseases,and determine whether it can be considered as a biomarker for differential diagnosis.Methods Detected serum NMO-IgG in 34 NMO patients,22 MS patients,24 high risk syndrome,5 clinical isolated syndrome,and 35 patients with other neumlogical diseases.Compared the clinic features(onset age,severity,prognosis,MRI lesions,autoimmune antibodies,CSF)of 34 NMO patients and 22 MS patients.Results The onset age of NMO is older than that of MS.It is more severe and with worse prognosis than MS.Longitudinal spinal cord lesions are easily found in NMO.NMO-IgG positive rate in NMO and high risk syndrome patients are 58.8% (20/34)and 45.8%(11/24)respectively,which are higher than that in MS(1/22),clinical isolated syndrome(1/5)and other neurological diseases(1/35;x2=37.2,P<0.01).The positive rate may have a relationship with the length of spinal cord lesions.Condusions MS and NMO are probably different diseases.NMO-IgG positive rate in NMO is significandy higher than that in MS,it can be considered as a biomarker for differential diagnosis.
