Prevention of recurrence and metastasis of hepatocellular carcinoma following liver transplantation: a systematic review

VernacularTitle:预防肝癌肝移植后肿瘤复发转移的研究进展
Author: Xianfeng CHEN ; Zuojin LIU
Publication Type:Journal Article
Keywords: Hepatocellnlar carcinoma (HCC); Liver transplantation (LT); Tumor metastasis; Recurrence
From: International Journal of Surgery 2010;37(5):335-339
CountryChina
Language:Chinese
Abstract: At present, about one third organ transplantation recipients were hepatocellular carcinoma (HCC) patients even in the most advanced transplant center in the world. HCC especially the early primary HCC has been listed as one of the indications of liver transplantation(LT) in the most organ transplant center in the world. However, due to the tumor recurrence and metastasis following LT, many patients would be dead following transplantation in about 2 years later. Their five-year survival rate was only 50 percent in benign final phase liver disease patients. The current researches for this phenomenon were still shallow both in mechanisms and treatments. How to prevent tumor recurrence has become serious challenges and must be faced in liver transplantation surgery. Obviously, to discover the molecular mechanisms and predisposing factors of following LT recurrence, to explore appropriate standards for LT in HCC patients and to strengthen perioperative management are the only way for increasing LT efficacy.