Meta-analysis of the risk factors of aseptic necrosis of bone in patients with systemic lupus erythematosus

VernacularTitle:系统性红斑狼疮并发无菌性骨坏死危险因素的Meta分析
Author: Guiye LI ; Mengjun ZHAO ; Li MA ; Guochun WANG ; Donghai WU
Publication Type:Journal Article
Keywords: Meta-analysis; Lupus erythematosus,systemic; Osteonecrosis
From: Chinese Journal of Rheumatology 2010;14(5):312-316
CountryChina
Language:Chinese
Abstract: Objective To investigate the major risk factors of aseptic necrosis of bone in patients with systemic lupus erythemattrsus (SLE),and thus provide evidence for decision-making on prevention.Methods Meta-analysis Was used to systemically evaluate the 14 case-control studies about the risk factors of aseptic necrosis of bone in patients with SLE.Review Manager 4.2 Was utilized to carry out homogeneity checking and calculate the pooled odds ratio (OR) with 95% confidence interval.Results The OR values of risk factor of AVN in patients with SLE and 95% CI were as follows:Raynaud's phenomenon 2.43(1.12～5.29):dental ulcer 2.33(1.11～4.88);renal involvement 1.76(1.27～2.44);vasculitis 4.65(1.62～13.33):hyperlipidemia 3.28(1.76～6.12);anti-phospholipid antibody(APL)2.06(0.84～5.06):hypocomplementemia 0.63(0.35～1.14).Conclusion Glucocorticosteroid is an important risk factor in inducing aseptic necrosis of bone in patients with SLE,but it is not the only factor.Raynaud's phenomenon,dental ulcer,renal involve-ment,vasculitis and hyperlipidemia are major risk factors of aseptic necrosis of bone in patients with SLE.