Clinical significance of CD3+CD56+ natural killer T cells in patients with systemic lupus erythematosus

VernacularTitle:CD3+CD56+自然杀伤T细胞在系统性红斑狼疮中的检测及意义
Author: Jing ZHU ; Bin ZHOU ; Jianbo ZHANG ; Jian LIU ; Wubin LONG
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Killer cells,natural; Flow cytometry
From: Chinese Journal of Rheumatology 2010;14(5):320-322
CountryChina
Language:Chinese
Abstract: Objective To investigate the alteration of NKT cells number in patients with systemic lupus erythematosus (SLE) and its correlation with SLE disease activity.Methods Blood samples were obtained from 30 patients with SLE and 30 healthy control subiects.The number of NKT cells from peripherial blood mononuclear cells (PBMC) were detect by flow cytometry (FCM).Two independent samples t-test and Pearson correlation was used to evaluated the relationship between SLE disease activity and NKT cells.Results Compared with healthy controls [(4.16±0.22)%],lower number of NKT cells were found in SLE group[(2.53±0.33)%](P<0.05).An inverse correlation was observed between the frequency of NKT cells and IgG,anti-dsDNA,SLE disease activity index.Conclusion Reduced proportions of NKT cells observed in patients with SLE and is associated with high SLE disease activity.