Association study of schizophrenia and phosphodiesterase 4B gene polymorphism
10.3760/cma.j.issn.1674-6554.2010.05.014
- VernacularTitle:磷酸二酯酶4B基因多态性与精神分裂症的关联研究
- Author:
Li ZHANG
;
Yuantang CHEN
;
Changjiang HE
;
Lei AO
;
Yangling XING
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Phosphodiesterase 4B gene;
Polymorphism;
Association analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(5):429-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the genetic association between schizophrenia and polymorphism of phosphodiesterase 4B (PDE4B) gene. Methods Observed in a sample of 98 parent/offspring trios where the proband net the Amerecan Classification and diagnostic Criteria for Mental Disorders The Forth Revised Edition,criteria for schizophrenia using correlation analysis and haplotype relative risk analysis. The polymorphism of phosphodiesterase 4B gene was detected with PCR methods and SNP typing in all nucleus families. Results The rs2180335 al-lele was connected with schizophrenia (P = 0.02131). Allele A was protective factor (Z = -2. 184) and allele G was the hazard factor (Z = 2.184). The frequency of rs2180335 allele A was 0.452 and the allele G was 0.548. The rs1040716, rs 3767311 and rs472952 allele was independence with schizophrenia. Five kinds haplotypes of A/A in the rs2180335-rs3767311, A/A in the rs 3767311-rs472952, A/A/A in the rs2180335-rs3767311-rs472952,A/G/G/A and T/A/A/A in the rs1040716-rs2180335-rs3767311-rs472952 associated with schizophrenia (P values were 0. 028715,0. 034845,0. 024177,0. 023967,0. 010839,genotype frequencies were 0. 223, 0.223,0.127,0.081,0.073). Conclusion It shows an association between schizophrenia and the rs2180335 polymorphism at nucleotide of phosphodiesterase 4B gene in Chinese.
