The observation of side effects and immunogenicity for the application of domestic lyophilized non-adjuvanted rabies Vero-cell vaccine against rabies for the post-exposure group
10.3760/cma.j.issn.1674-6554.2010.05.023
- VernacularTitle:国产冻干无佐剂Vero细胞狂犬病疫苗对暴露后人群接种反应及免疫原性观察
- Author:
Shenwen QU
;
Weifang YANG
;
Yumin LIANG
;
Linlin YANG
;
Mingxia CHEN
;
Jing XU
;
Fuhe ZHAO
;
Liming ZHANG
;
Xia SI
;
Congling YANG
- Publication Type:Journal Article
- Keywords:
Rabies;
Lyophilized Vero cell rabies vaccine;
Immunogenicity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(5):456-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the vaccination reactions and immunogenicity of the application of lyophilized Vero cell rabies vaccine without adjuvant in a way of low-dose intradermal injection for post-exposure group. Methods Conducting post-exposure immunization for 256 persons with the class Ⅱ level exposure to rabies. Based on a randomized, single-blind principle, all subjects were divided into intradermal injection (ID) group (n= 128),injected 0.1 ml for each site in accordance with 0,3,7,28,90 d,2 sites,2 sites,2sites,1 site,1 site respectively, and intramuscular injection(IM) group(n= 128) in accordance with 0,3,7,14,28 d in full-volume (0.5ml) PVRV Deltoid injection. The local and systemic vaccination reactions were observed for the different injection ways. The indirect sandwich ELISA assay was used to analyze the antibody levels. Results For the intradermal injection group, the incidence rates for local redness and swelling, induration, pain, itch were 1.27%, 0.29% ,0.49% ,11.43% respectively,for the intramuscular group, the incidence rates were 1.09% ,0. 16% ,2. 81% ,1.41% respectively. From the point of systemic reactions,the incidence rates of fever,rash,headache,fatigue and weakness were 0.31 % ,0. 16% ,0. 31 % , 1.09% respectively in the intradermal injection group,and the rates were 0.31% ,0.31% ,0.63% , 1.09% respectively in intramuscular group. All the adverse effects often occurred following the 1st,2nd injection. The seroconversion rates for intradermal injection and intramuscular were 94.53% ,95.31% following 14 d immunization respectively,the rates were 96. 83% ,97.64% following 42 d immunization respectively. For the post-exposure group,no statistical difference in significance was found between the two seroconversion rates. Conclusion For the application of domestic lyophilized Vero cell rabies vaccine,its adverse reactions are mild,and immunogenicity is good.
