The observation of the influence about left heart function in obstructive sleep apnea by chronic intermittent hypoxia
10.3760/cma.j.issn.1008-1372.2010.05.002
- VernacularTitle:慢性间断组织缺氧对阻塞性睡眠呼吸暂停综合征患者左心功能影响的观察
- Author:
King WANG
;
Mingxian LI
;
Jianguo XU
- Publication Type:Journal Article
- Keywords:
Anoxia;
Sleep apnea,Obstructive/CO/TH;
Ventricular function,left;
Positive-pressure respiration
- From:
Journal of Chinese Physician
2010;12(5):581-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of left heart function in obstructive sleep apnea by CIH, and explore left heart function before and after CPAP. Methods 75 OSA were divided into two groups. Blood pressures of 40 patients were coincident with diagnostic standard of hypertension and 35 patients did not have hypertension. The control group included 30 healthy adults. The blood pressures before and after sleep, left ventricular ejection fraction(LVEF) ,shortening fraction(FS) , E, A and E/A were compared with those of normal control subjects. BP, LVEF and E/A after CPAP were also analyzed. Results Multiple parameters including LVEF[ ( 56.40 ±9.74)% ] , FS[ (33. 80 ±6.16)% ] and E/A (0. 87 ±0.17) , were impaired in OSA patients relative to the control subjects ( P <0. 05 orP <0.01). E/A was significantly decreased in obstructive sleep apnea unallied hypertension than that in normal control subjects. E/A was conspicuously decreased in obstructive sleep apnea patients associated hypertension comparing with that in obstructive sleep apnea unallied hypertension. After CPAP for 6 months, in these obstructive sleep apnea associated hypertension patients, LVEF [(59.70 ±11. 1)%] was increased than that before treatment[ (56. 40 ± 9.74)% ] ( P <0.05), and E/A (1.16 ± 0. 25 ) was higher than that before treatment (0. 87 ±0. 17) ( P <0.01). Conclusion CIH may affect left heart structure and function. These changes were aggravated with hypertension. CPAP treatment had important effects in the treatment of cardiovascular function, and it could improve the life quality.
