Expression of HIF-1α and survivin and their relationship in renal clear cell carcinoma

VernacularTitle:肾透明细胞癌中HIF-1α和Survivin表达及其相关性研究
Author: Bing SHI ; Ranglang HUANG
Publication Type:Journal Article
Keywords: Kidney neoplasms/ME; Adenocarcinoma,clear cell/ME; Hypoxia-inducible factor1,alpha Subunit/ME; Microrubule-associated proteins/ME
From: Journal of Chinese Physician 2010;12(5):600-602
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of HIF-1α and survivin in renal clear cell carcinoma (RCC) and normal renal tissue ( NRT) and explore the correlation between HIF-1α and survivin expression. Method SABC immunohistochemical staining was performed to detect the expression in 32 cases of RCC and 10 cases of NRT.Results The level of positive HIF-1α immunostaining in RCC(0. 037 ±0. 0182,0. 093 ±0. 0384,respectively) was higher than NRT(0. 008 ±0.0055,0. 014 ±0. 0059, respectively) ( P<0. 05). The level of positive survivin immunostaining in RCC(0. 053 ±0.0179,0. 137 ±0.0291) was higher than NRT( P<0. 05). The expression of HIF-1α and survivin had positive relationship with clinical stage in RCC(0. 029 ±0. 0117,0.070±0.0154)( P <0.05). The expression of HIF-la had relation with survivin in RCC( r = 0. 655, P < 0. 05).Conclusion The expression of HIF-1α was strongly positive correlated with survivin ( r = 1.000,0. 655, P <0. 05).