A Case of Chronic Myelogenous Leukemia with ider(22)(q10)t(9;22)(q34;q11.2) as Clonal Evolution.
- Author:
Eun Hae KIM
1
;
Hee Soon CHO
;
Chae Hoon LEE
;
Kyung Dong KIM
;
Myung Soo HYUN
;
Sung Hwa BAE
Author Information
1. Department of Laboratory Medicine, College of Medicine, Yeungnam University. chscp@hanmail.net
- Publication Type:Case Report
- Keywords:
Ider(22)(q10)t(9;
22)(q34;
q11.2);
Clonal evolution;
Ph+ CML
- MeSH:
Chromosome Aberrations;
Clonal Evolution*;
Disease Progression;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*;
Philadelphia Chromosome;
Prognosis
- From:The Korean Journal of Laboratory Medicine
2003;23(3):139-142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The ider(22)(q10)t(9;22)(q34;q11.2) is a rare secondary karyotypic aberration of Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) and was associated with disease progression and poor clinical outcomes in most of the previously reported cases. We experienced a case of Ph+ CML with the occurrence of ider(22)(q10)t(9;22)(q34;q11.2) as clonal evolution preceding an hematologic feature of accelerated phase for 3 years. So this chromosomal abnormality was not always correlated with poor prognosis. Relevant literature was reviewed.
