Effects of valsartan on plasma resistin and microinflammation in patients with maintenance hemodialysis

VernacularTitle:缬沙坦对维持性血液透析患者抵抗素与微炎症状态的影响
Author: Yanfang SONG ; Hong ZHANG ; Yan XU ; Qifeng ZHANG
Publication Type:Journal Article
Keywords: Renal dialysis; Valsartan
From: Chinese Journal of General Practitioners 2010;9(6):422-423
CountryChina
Language:Chinese
Abstract: In total, 106 patients with maintenance hemodialysis (MHD) were divided into two groups based on their valsartan administration, and 53 healthy controls were recruited in the study. Plasma concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), resistin and high sensitivity C-reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay (ELISA) before and after valsartan treatment. Plasma levels of resistin, IL-6, TNF-α and hs-CRP were all significantly increased in patients with MHD as compared to those in healthy controls (P＜0. 05). Among patients with MHD the plasma levels of resistin, IL-6 and hs-CRP in valsartan group were lower than those in non-valsartan group (P＜0. 05).