Effects of tirofiban administration to myocardial ischemical reperfusion injury during primary percutaneous coronary intervention
10.3760/cma.j.issn.1671-0282.2010.05.011
- VernacularTitle:替罗非班对直接冠脉介入术中心肌缺血-再灌注损伤的影响
- Author:
Shaonan LI
;
Guanglian LI
;
Yi LUO
;
Chong ZENG
;
Yizhi PAN
;
Xiaoming LEI
;
Zhen LU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Ischemical reperfusion injury,myocardial;
Angioplasty,transluminal,percutaneous coronary;
Platelet membrane glycoproteins
- From:
Chinese Journal of Emergency Medicine
2010;19(5):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and the mechanism of tirofiban administration in myocardial ischemical reperfusion injury(MIRI) in patients with acute myocardial infarction(AMI) undergoing primary percutaneous coronary intervention(PCI). Method The study included 158 STEMI Patients who accepted primary PCI therapy and were randomly (random number) divided into two groups: tirofiban administration group and control group. Incidence of MIRI during PCI, Correct TIMI frame count(CTFC), ST segment resolution(STR), peak value and peak time of MB isoenzyme of creatine kinase( CK-MB), and incidence of major adverse cardiac events (MACE) during 30 days postoperation in both groups were measured. Results Tirofiban administration group was superior to control group in terms of incidence of MIRI, CTFC, STR, peak value and peak time of CK-MB, and incidence of MACE during 30 days postoperation (P < 0.05). Multiple factor logistic regression analysis indicated that intravenous tirofiban administration before primary PCI was the independently protective factor for MIRI. Conclusions Intravenous tirofiban administration in patients with STEMI before primary PCI can significantly decrease the incidence of MIRI,reduce myocardial damage and improve the prognosis.
