Prognosis of distal bile duct cancer patients afar surgical resection
10.3760/cma.j.issn.1007-631X.2010.06.017
- VernacularTitle:远端胆管癌切除患者术后生存的影响因素分析
- Author:
Yiping LU
;
Lei CHEN
;
Qilu QIAO
;
Guosheng FENG
;
Nengwei ZHANG
;
Guangzhong XU
;
Xisheng LENG
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
Pancreaticoduodenectomy;
Survival
- From:
Chinese Journal of General Surgery
2010;25(6):476-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study prognostic factors after surgical resection for distal bile duct cancer. Methods A retrospective muhicenter clinical analysis,including Beijing Shijitan Hospital,Peking University People's Hospital and Peking University First Hospital,was made for 103 patients of distal bile duct cancer receiving surgical resection from 1995 to 2009.Potential clinicopathological prognostic factors were examined bv univariate and multivariate survival analysis. Results The 1.3 and 5 years overall survival rate was 72%,41%and 25% respectively (median survival time,24.13 months).Univariate analysis revealed operative modality,lymph node status,surgical margin and TNM stage as significant factors influencing postoperative survival.Positive surgical margin,lymph node metastasis and TNM stage were significant independent predictors of poor prognosis by a Cox proportional hazards regression model. Condusions Surgical margin margin,lymph node metastasis and TNM stage were the most important prognostic factors for bile duct carcinoma after resection.Radical pancreaticoduodenectomy was the choice of therapy for distal bile duct carcinoma.
