Effect of resveratrol on glucose-stimulated insulin secretion in isolated rat pancreatic islets
10.3760/cma.j.issn.1000-6699.2010.06.017
- VernacularTitle:白藜芦醇对原代大鼠胰岛葡萄糖刺激的胰岛素分泌的影响
- Author:
Hongmei LONG
;
Xiao WANG
;
Fengying LI
;
Aifang NIE
;
Yun LIU
;
Ling WU
;
Libin ZHOU
;
Huanzhen CHEN
;
Cuiping ZHANG
;
Guo LI
- Publication Type:Journal Article
- Keywords:
Resveratrol;
Insulin secretion;
Calcium ion;
Lipotoxicity
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(6):495-497
- CountryChina
- Language:Chinese
-
Abstract:
Isolated freshly rat islets were transferred to 24-well plates and incubated with different concentrations of glucose or resveratrol for 1 or 24 h.The results showed that resveratrol dose-dependently inhibited glucose-stimulated insulin secretion from isolated rat islets after 1 h incubation,with 10%,35%,and 80% (P<0.05 or P<0.01) decrease at the concentrations of 1,I0,and 100 μmol/L.10 μmol/L resveratrol decreased the intracellular calcium concentration by 60% (P<0.05).After incubation for 24 h,resveratrol increased palmitatesuppressed insulin secretion to 75% (P<0.01) of control.These results suggest that resveratrol acutely inhibits insulin secretion from primary pancreatic islet via regulating intracellular calcium ion concentration,and in the long run resveratrol may protect β-cells from lipotoxicity.
