Changes of skeletal muscle structure and insulin resistance in low birth weight rat
10.3760/cma.j.issn.1000-6699.2010.06.019
- VernacularTitle:低出生体重大鼠发育期骨骼肌形态结构变化及胰岛素抵抗情况
- Author:
Wen LI
;
Zongde XIE
;
Jianfang GE
;
Jintao HU
;
Pingyang CHEN
;
Suping LI
- Publication Type:Journal Article
- Keywords:
Low birth weight;
Rats,Sprague-Dawley;
Skeletal muscle;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(6):501-503
- CountryChina
- Language:Chinese
-
Abstract:
To study the changes in skeletal muscle structure and insulin resistance of low birth weight rats.The low birth weight filial rat model was established by feeding low protein diet to the pregnant rat during gestation.At 7 d,21 d,and 2 months,blood glucose and serum insulin were measured,and the structure of skeletal muscle was observed.From 7 d to 2 months,the muscle fibers of low birth weight rat were atrophic and arranged in disorder.The ultrastructure of skeletal muscle was also abnormal distinctly at 2 months.No differences of blood glucose and rerum insulin were found between the two groups.
