Association study between the genetic polymorphism of 15 STR loci and the crime of rape
10.3760/cma.j.issn.1674-6554.2010.05.012
- VernacularTitle:STR基因座多态性与强奸犯的关联研究
- Author:
Chun YANG
;
Huajie BA
;
Zhiqin GAO
;
Ziqing LIN
;
Hanqing ZHAO
;
Bingquan LIU
;
Jun MA
;
Aihua ZHU
- Publication Type:Journal Article
- Keywords:
Rapist;
Short tandem repeats (STRs);
Human chromosome;
Association study
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(5):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between rapists and related allele genes based on the analysis of 15 short tandem repeats (STRs) loci genetic polymorphism. Methods The method of Genome-wide scan was being used. Buccal swab samples of 129 rapists and 156 random populations were collected and PCR compound amplification was carried out with the aid of AmpFISTR Identifiler system. Then the products were subjected to electrophoresis and gene detection with AB13100 type gene analysis system so as to calculate and compare the alleles of 15 STRs gene frequency in the two groups. Results All the 15 STRs loci allele gene frequency in rapists and random population was found to coincide with Hardy-Weinberg law(P>0. 05). Allele 28 of D21S11 (rapists: 1.55% ,control group:5. 13%) ,allele22 of FGA(rapists:24.03% ,control group:16.99%),allele23 of FGA(rapists: 17.05% ,control group:26.28%) ,allele 10 of TH01(rapists:1.16% ,control group:4.17%) ,allele 8 of TPOX(rapists:55.77% ,control group:63.77%),allele 12 of TPOX(rapists:4.26% ,control group: 1.28%) were different between the two groups (P< 0.05) .while it is no differ significantly in other STRs loci allele gene(P >0.05). Conclusion Allele 28 of D21 S11,allele 22 and 23 of FGA, allele 10 of TH01, allele 8 and 12 of TPOX may be associated with the violent crime of rape. It is suggested that there are existing sensitive or resistance genes about the violent crime of rape in chromosome 2,4,11,21.
