The role of estrogen in the hepatocarcinogenesis
10.3760/cma.j.issn.1673-4203.2010.05.014
- VernacularTitle:雌激素在肝癌发生发展中作用的研究
- Author:
Shengjin HAN
;
Geliang XU
;
Weidong JIA
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Estrogen;
Receptor,interleukin 6;
Diethylnitrosamine
- From:
International Journal of Surgery
2010;37(5):332-334
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is a major disease for serious threat to human health, ranked third in the world of cancer causes of death and second in China' s in cancer mortality. There are gender differences in the incidence of HCC and numerous studies on estrogen' s role in the formation of HCC, and the formation of estrogen in the liver plays a protective role during the hepatocarcinogenesis. Some studies have shown estrogen inhibiting the expression of interleukin-6 thereby reducing the incidence of HCC. IL-6 and HGF have an important role in promoting HCC formation process, estrogen and these factors have are also important links. Now require in-depth exploration of novel adjuvant therapy is required to improve the survival rate of patients with HCC.
