Application of atopy patch test in diagnosing egg and milk allergy among children with atopic dermatitis
10.3760/cma.j.issn.0412-4030.2010.06.003
- VernacularTitle:特应性斑贴试验在诊断特应性皮炎患儿鸡蛋、牛奶过敏中的价值
- Author:
Huan YANG
;
Yizhu XIAO
;
Xiaoyan LUO
;
Ying OUYANG
;
Yongmei LI
;
Qi TAN
;
Juan XIANG
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
Patch tests;
Dermatitis,atopic;
Egg hypersensitivity;
Milk hypersensitivity;
Child
- From:
Chinese Journal of Dermatology
2010;43(6):378-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the capacity of atopy patch test in diagnosis of food allergy in children with atopic dermatitis (AD).Methods Egg and milk,as the most common food allergens among Chinese children,were employed in this study.Skin prick test (SPT) and atopy patch test (APT) with fresh egg and milk were carried out in 68 children with AD.Oral food challenges in an open style were performed to confirm the diagnosis of food allergy.Resuits Of these patients,58(85.3%)were sensitive to egg,40(58.8%)to milk and 34(50.0%) to both.Of 98 patients with positive challenge,47 showed late response,10 immediate reactions.and 41 mixed reactions.The sensitivity,specificity,positive predictive value (PPV),negative predictive value (NPV) and the agreement with food challenges in diagnosis of egg/milk allergy were 96.6%/67.5%.90.0%/82.1%,98.2%/84.4%,81.8%/63.9% and 95.6%/73.5%,respectively for APT alone,37.9%/30.0%,100%/89.3%,100%/80.0%,21.7%/47.2% and 47.1%/54.4%,respectively for SPT alone.APT was found to be more sensitive in diagnosis of late-phase reactions than SPT (P<0.01).No significant difference was found in the sensitivity between APT alone and the combination of APT and SPT in parallel algorithm for diagnosis of egg or milk allergy (x2=0.509,0.549,both P>0.05) or in the specificity between APT alone and that in serial algorithm( P=1.000;x2=3.514,P>0.05).Conclusions APT is superior to SPT in diagnosis of late responses to food,and the combination of SPT and APT does not facilitate the diagnosis of food or milk allergy compared with APT alone.
