Changes and clinical significance of serum high sensitivity C-reactive protein in acute cerebral infarction patients with different etiological types
10.3760/cma.j.issn.1008-6315.2010.05.004
- VernacularTitle:不同病因学亚型急性脑梗死患者超敏C-反应蛋白的动态变化及临床意义
- Author:
Ronggui WANG
;
Yanling DONG
;
Xinjing LIN
;
Yaoxuan LI
;
Demin ZHANG
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
High-sensitive C-reactive protein;
Neurologic impairment
- From:
Clinical Medicine of China
2010;26(5):459-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate dynamic changes and clinical significance of the high-sensitive Creactive protein(hs-CRP) level in acute cerebral infarction patients with different etiological types.Methods 136 patients with acute cerebral infarction were recruited.These patients were classified into five subtypes based on Trial of Org 10172 in Acute Stroke Treatment(TOAST) criteria.Serum hs-CRP levels on the 1st,3rd,5th,7th,14th day after onset from patients and 42 healthy controls were measured with immunoturbidimetry.The neurologic impairmentscore was determined with NIHSS.Results Serum hs-CRP levels is higher on the 1th,3rd,5th,7th,14th day than that of the control group ( (4.26 ± 1.31 ),( 12.57 ± 6.29 ),( 10.23 ± 4.49 ),(7.54 ± 2.33 ),(4.25 ± 1.77) mg/Land (2.56 ± 0.86) mg/L,t = 7.89,10.26,10.99,13.55,5.97,P ＜ 0.05 ).Among 5 subtypes,serum hs-CRP was the highest in large-artery atherosclerosis group after acute ischemic stroke,and cardioembolism group was the next.Serum hs-CRP reached the highest on three or five days after disease onset and decreased slowly.High levels of hs-CRP in large-artery atherosclerosis group indicated severe neurologic functional impairment and worsen prognosis.Conclusions ACI is closely related to serum hs-CRP level,which can be used as an subjective index for severity and prognosis with the lasting,high levels of hs-CRP levels predict poor prognosis.
