Visfatin inhibits pancreatic β-cell line MIN6 apoptosis via PI3K-Akt and MAPK-ERK1/2 signaling pathways
10.3760/cma.j.issn.1000-6699.2010.06.018
- VernacularTitle:内脂素激活PI3K-Akt和MAPK-ERK1/2信号通路抑制MIN6细胞凋亡
- Author:
Qun CHENG
;
Yongde PENG
;
Weiping DONG
;
Yifei WANG
;
Jingcheng WU
;
Xiaoying DING
- Publication Type:Journal Article
- Keywords:
Visfatin;
Protein kinase B;
Extracellular-signal regulating kinase 1/2;
MIN6 cells;
Apoptosis
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(6):498-500
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects and the mechanism of visfatin on MIN6 cell signaling pathway and apoptosis induced by palmitate.Human recombinant visfatin promotes protein kinase B (Akt) and extracellularsignal regulating kinase (ERK)1/2 phosphorylation in dose-and time-dependent manner,and prevents MIN6 cell from apoptosis induced by palmitate (P<0.05 or P<0.01).The activation of Akt and ERK1/2 signaling pathway may be one of the molecular mechanisms of visfatin.
