The correlation between HLA-A allele and anaphylactoid purpura in children of Mongolia
10.3760/cma.j.issn.1008-6706.2010.06.018
- VernacularTitle:蒙古族儿童过敏性紫癜与HLA-A基因的关联性
- Author:
Chunzhi LIU
;
Shaomin REN
;
Chao MA
- Publication Type:Journal Article
- Keywords:
AP;
children,Mongolia;
HLA-A;
Gene;
PCR-SSO
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(6):758-760
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the association between HLA -A gene and anaphylactoid purpura(AP) in children of Mongolia in Inner Mongolia. To find correlated genes and study part of pathogenesis and the method of prevention and cure of AP. MethodsThe method of case control was adopted and selected 56 children with AP as case group and 66 health children as control group in Mongolia,who had resided in Inner Mongolia three generations without consanguinity, history of mixed, marriages, other medical history , and family history of immunity,led into polymerase chain reaction sequence specific oligonucleotide probes technique, analyzed the type of HLA-A gene. The compare of gene frenquency made with logistic regression after χ2 or Fisher test. ResultsThe gene frenquency of HLA- A * 11 ( 16. 1% ) allele in case group compared to that of control group( 9. 1% ) ,Wald of HLA-A * 11 gene was 3. 954 ,P =0. 047, the difference had statistical significance. B = 0. 844 > 0, OR = 2. 325 > 1, it helped development of the disease,which 95％confident interval was 1. 012-5.340,which did not include 1 ,EF =0. 342 >0. ConclusionHLA-A * 11 allele may be the susceptible gene of AP in children of Mongolia in Inner Mongolia.
