The present understanding of serine proteinase inhibitor-9
10.3760/cma.j.issn.1673-4203.2010.06.015
- VernacularTitle:丝氨酸蛋白酶抑制剂PI-9的研究进展
- Author:
Xiaoye LEI
;
Yejiang ZHOU
- Publication Type:Journal Article
- Keywords:
Serine proteinase inhibitor 9;
Inflammation;
Transplantation;
Tumor
- From:
International Journal of Surgery
2010;37(6):404-407
- CountryChina
- Language:Chinese
-
Abstract:
Serine proteinase inhibitor9(P1-9),a charac-teristic member of serpins,has been identified as the only inhibitor of granzyme B(GrB).Accumulated evidence suggested that PI-9 inhibits GrB-induced apoptosis by blocking DNA fragmentation of target cell.Physiologically,PI-9 could protect cytotoxic lymphocytes from committing autolysis or fratricide,and play an important role in facilitating immunologic tolerance of immune-privileged sites.In addition,evidences in recent years suggest that PI-9 Was also involved in vailous pathologic processes,such as inflammation,trans plantation and immune tolerance of tumor.
