Investigation on the role of Tumor necrosis factor-α and interleukin-6 in preterm labor
10.3760/cma.j.issn.1008-6706.2010.06.013
- VernacularTitle:血清肿瘤坏死因子和白细胞介素-6与早产的关系研究
- Author:
Longying SHEN
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-α;
Interleukin- 6;
Preterm labor;
Intrauterine infection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(6):747-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of tumor necrosis factor-α(TNF-α) and: Interleukin-6 (IL-6) in preterm labor. Methods We collected 58 cases maternal serum and partial placental tissues of preterm labor (32 cases of infectious group with chorioamnionitis, 26 cases of noninfectious group without chorioamnionitis), and 28 cases maternal serum of term labor in corresponding period were collected. In 86 cases serum levels of TNF-α and IL-6 were measured by enzyme -linked immunosorbent assay (ELISA). Results The levels of maternal serum TNF-α and IL-6 in preterm labor with chorioamnionitis were significantly higher than those of preterm labor without chorioamnionitis and term labor( P < 0.05 ). Conclusion The increase of TNF-α and IL-6 level is closely related to preterm labor with chorioamnionitis, and the detecting of TNF-α and IL-6 level is valuable in predicting premature delivery.
