Effect of troglitazone on insulin secretion in pancreatic β-cells and its mechanism
10.3760/cma.j.issn.1000-6699.2010.06.016
- VernacularTitle:曲格列酮对胰岛β细胞胰岛素分泌的影响及机制研究
- Author:
Ling WU
;
Xiao WANG
;
Libin ZHOU
;
Fengying LI
;
Huanzhen CHEN
;
Hongli ZHANG
;
Yun LIU
;
Cuiping ZHANG
;
Hongmei LONG
;
Wenyi LI
;
Guo LI
- Publication Type:Journal Article
- Keywords:
Troglitazone;
Glucose-stimulated insulin secretion;
AMP-activated protein kinase
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(6):493-495
- CountryChina
- Language:Chinese
-
Abstract:
The effect of troglitazone on glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells and its mechanism were investigated.10 μmol/L troglitazone had no effect on basal insulin secretion,but significantly decreased GSIS and stimulated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylations (all P<0.01).These reactions were completely reversed by AMPK inhibitor compound C,suggesting that the troglitazone acutely inhibits insulin secretion via stimulating AMPK activity in beta cells.
