Study of coagulation function in patients of systemic inflammatory response syndrome
10.3760/cma.j.issn.1008-6315.2010.06.019
- VernacularTitle:全身炎症反应综合征患者凝血功能的研究
- Author:
Xin WANG
- Publication Type:Journal Article
- Keywords:
Systemic inflammatory syndrome;
Coagulation function;
Coagulant;
Anticoagulant;
Fibrinloytic system
- From:
Clinical Medicine of China
2010;26(6):610-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of coagulation function in the patients of systemic inflammatory response syndrome (SIRS) , and to provide evidences on anticoagulation therapy. Methods All of the patients in ICU were divided into two groups: SIRS (30 patients) and non-SIRS(25 patients). Thirty healthy adults were recruited as controls. Prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) , fibrinogen(FIB),levels of platelet (PLT) and D-dimer were measured in all patients and healthy adults. Results The levels of PT, APTT,TT.DD in the SIRS group((16.48 ± 1. 57) s, (22. 67 ± 1. 48) s, (43. 56 ±4.33)s and (2.25 ±0.18)mg/L respectively) were significantly higher than those in the non-SIRS group((12. 83 ± 1.23)s, (17. 05 ±1. 97)s,(33. 34 ±2. 38)s and(0. 58 ±0. 15)mg/L respectively)and the control group ((12. 04 ±0. 98) s,(16. 88 ±1. 37)s,(29. 84 ±1.98)s and (0.43 ±0. 11)mg/L respectively) (P <0. 05). The levels of PLT,FIB in the SIRS group((110. 69 ±50. 23) × 109/L and(2. 05 ±0. 33) g/L, respectively) were significantly lower than those in the non-SIRS group((180. 58 ±45. 70) × 109/L and(3. 54 ±0. 29)g/L,respectively)and the control group ((204. 95 ± 46. 83) × 109/L and (3. 78 ± 0. 54) g/L, respectively) (P < 0. 05). Conclusions The dysfunction of coagulation exits in SIRS. Coagulation system abnormity might play an important role in the development of SIRS.
