An analysis of efficacy and related factors of itraconazole in the treatment of invasive fungal infection in hematological diseases
10.3760/cma.j.issn.0578-1426.2010.06.014
- VernacularTitle:伊曲康唑治疗血液病患者侵袭性真菌感染的疗效及影响因素分析
- Author:
Chunyan LIU
;
Rong FU
;
Yuhong WU
;
Erbao RUAN
;
Wen QU
;
Guojin WANG
;
Yong UANG
;
Xiaoming WANG
;
Hong UU
;
Jia SONG
;
Jing GUAN
;
Huaquan WANG
;
Limin XING
;
Lijuan LI
;
Jun WANG
;
Zonghong SHAO
- Publication Type:Journal Article
- Keywords:
Fungus;
Itraconazole;
Blood disease
- From:
Chinese Journal of Internal Medicine
2010;49(6):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and related factors of itraconazole in the treatment of invasive fungal infection (IFI) in the patients with blood diseases ( BD). Methods A total of 156 BD patients with IFI treated with itraconazole in General Hospital, Tianjin Medical University from 2005 to 2008, were retrospectively analyzed. Results Of these patients, 92 were with underlying malignant BD, and 64 with non-malignant BD; 77 possible IFI, and others proven IFI. A total of 94 (63. 5% ) patients were responded to itraconazole successfully, while 54 (36. 5% ) failed. The underlying malignant BD, post-chemotherapy, neutrophil count less than 0. 5 x 109/L, positive fungus culture, and bacteria infection were related with the response to itraconazole significantly, while patient's age, application of other antibiotics,positive C test, IFI localization, haemoglobin level and platelet counts were not Five patients was changed other anti-IFI therapy because of side effects, including gastrointestinal ill (3 cases with nausea or vomiting) and tachycardia (2 cases). Conclusions Itraconazole was effective and safe in the treatment of IFI in the patients with BD. Underlying malignant BD, agranulocytosis, bacteria infection, and delayed anti-IFI therapy might reduce itraconazole therapeutic effects.
