Leptin's role in the tumorigenesis and progression of breast cancer
10.3760/cma.j.issn.1673-4203.2010.06.016
- VernacularTitle:瘦素在乳腺癌发病中的作用
- Author:
Xianghou XIA
;
Junchao GU
- Publication Type:Journal Article
- Keywords:
Leptin;
Breast cancer;
Neoplasm
- From:
International Journal of Surgery
2010;37(6):407-410
- CountryChina
- Language:Chinese
-
Abstract:
Leptin,a 16 kD protein encoded by ob gene,has been shown to play a pivotal role in satiaty control and adipose metabolism.However,numemus recent studies indicme that leptin may also take part in mammary cells transformation,proliferation and angiogensis.Those evidences suggest that leptin has an important role in the mammary cell tumorigenesis and progession,but the undedine mechanism needs further exploration.Our aim is to review the current andvances on leptin's role in tumourigenesis and progression of breast cancer from perspectives of in vitro,aniamal model and breast cancer biopsy studies.
