Expressions of matrix metalloproteinase-9,IV collagen and CD34 in epithelial ovarian tumor and its significance
10.3760/cma.j.issn.1673-4904.2010.15.001
- VernacularTitle:基质金属蛋白酶-9、Ⅳ型胶原、CD34在卵巢上皮性肿瘤中的表达及意义
- Author:
Kaiqing HUANG
;
Peiqi KE
;
Lizhi LIANG
;
Wenming PENG
;
Juan PENG
;
Shaoyan LIU
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Matrix metalloproteinase 9;
Collagen type IV;
Antigens,CD34
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(15):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of matrix metalloproteinase (MMP)-9, IV collagen and CD34 in epithelial ovarian tumor. Methods Eighty-two patients with epithelial ovarian tumor, among them,there were 48 malignant epithelial ovarian carcinomas, 23 borderline epithelial ovarian tumors and 11 benign epithelial ovarian tumors. The expression of MMP-9, IV collagen and CD34 were detected by immunohistochemistry. Results The expression of MMP-9 was strongly linked to the degree of malignant ovarian carcinomas (F= 39.306,P< 0.01). The expression of CD34 was also strongly linked to the degree of malignant ovarian carcinomas [benign epithelial ovarian tumors was (17.18±5.64)%,borderline epithelial ovarian tumors was (29.76±7.18)%,well-differentiated malignant epithelial ovarian carcinomas was (57.20±8.55)%,moderately-differentiated malignant epithelial ovarian carcinomas was (71.20±8.48)%, poorly-differentiated malignant epithelial ovarian carcinomas was(90.38±20.03)%](F= 100.072, P < 0.01). The expression of IV collagen in malignant epithelial ovarian carcinomas was different from that in borderline epithelial ovarian tumors and benign epithelial ovarian tumors (F = 11.554,P<0.0l). The expression of MMP-9 was positive correlation with the loss expression of IV collagen and the expression of CD34 (r=0.796,0.802,P< 0.01).Conclusions The positive expression of MMP-9,CD34 and the negative expression of IV collagen are obviously relevant to degree of malignant ovarian carcinomas.The combined testing on expression of MMP-9,CD34, IV collagen on ovarian carcinomas is significant to decide degree of malignant ovarian carcinomas and evaluate future development.
