The relationship of placental expression of leptin and disease development in patients with pre-eclampsia
10.3760/cma.j.issn.1673-4904.2010.12.005
- VernacularTitle:子痫前期患者胎盘组织瘦素的表达与病情的相关性研究
- Author:
Yongmei GAO
;
Yan WU
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Hypertension;
Leptin
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(12):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of placental expression of leptin and disease development in patients with pre-eclampsia.Methods The placental expression of leptin gene was determined in gestational hypertension(10 cases),mild pre-eclampsia(10 cases),Severe pre-eclampsia(10cases)and normal pregnant women(15 cases,control group)by reverse txanscription/polymerase chain reaction(RT/PCR).Meanwhile,24 hour urine protein and mean arterial blood pressure(MAP)were detected in patients with pre-eclampsia.Results The expression of leptin mRNA in placenta were significantly higher in severe and mild pre-eclarnpsia than that in normal pregnant women(0.507 ±0.036,0.476±0.023vs 0.441 ±0.030)(P＜0.01),meanwhile,in the severe pre-eclampsia was higher than that in the mild preeclampsia(P＜0.05).The difference was not significant between the gestafional hypertension(0.463±0.024)and the normal pregnant women(P＞0.05).There was a positive correlation between the placental leptin mRNA expression levels in pre-eclampsia and the 24 hour urine protein and MAP (P＜0.05).Conclusions The placental leptin mRNA expression levels in pre-eclampsia increase.The pre-eclampsia women placental hptin mRNA expression levels correlate with pathogenetie condition.The placental leptin mRNA expression levels in pre-eclampsia correlate,with disease development.
