Effect of urinary kallidinogenase on cerebral infarction with different etiological factor
10.3760/cma.j.issn.1673-4904.2010.12.008
- VernacularTitle:注射用尤瑞克林治疗不同病因分型脑梗死的疗效观察
- Author:
Wenxu ZHENG
;
Ping LIU
;
Lan YANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Urinary kallidinogenase
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(12):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and safety of urinary kallidinogenase on acute cerebral infarction.Methods One hundred and sixty-four patients with acute cerebral infarction were randomly divided into two groups:treatment group with urinary kallidinogenase(86 cases)and control group (78 cases).According to Chinese guidelines for prevention and management cerebrovascular disease,two groups were treated with basic therapy,such as antiplatelet,neurologic protection,blood pressure control,and so on.On basis of control group,treatment group Was administrated intravenous injection of urinary kallidinogenase 0.15 PNA U per day for 10 days.The primary efficacy Was evaluated by the National Institutes of Health Stroke Scale(NIHSS)score and Barthel index.Results The score of NIHSS and Barthel index at 15 days after treatment in the treatment group were higher than those in the control group[(6.67±3.02)scores vs(7.42±3.02)scores;75.36±23.56 vs 68.36±22.36,P＜0.05].Urinary kallidinogenase could significantly reduce neurological deficits in big artherosclerosis type by TOAST typing.Conclusion Urinary kallidinogenase may be effective and safe in the treatment of acute cerebral infarction.
