Postoperative radiotherapy concurrent with paclitaxel and cisplatin in the adjuvant treatment of gastric cancer:An analysis of 64 cases
10.3760/cma.j.issn.1008-6706.2010.09.023
- VernacularTitle:胃癌术后同步放化疗64例临床分析
- Author:
Xuebang ZHANG
;
Gang LI
;
Xia DENG
;
Changlin ZOU
;
Congying XIE
;
Zhao JING
;
Shixiu WU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemotherapy,adjuvant;
Radiotherapy,conformal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(9):1196-1198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of postoperative chemoradiation for D2 dissection gastric cancer,and to compare the difference of toxicity between confromal and traditional radiotherapy.Methods Sixty four patients with T3-4,N + or R1 were enrolled.Radioation was given to a total dose of 46Gy delivered in 23fractions by use of 3D-CRT or 4 fields traditional radiotherapy.Chemothrepy was administered with paclitaxel 135 mg/m2 day 1 and 29,cisplantin 20 mg/m2 day 1 ～3 and day 29 ～31 during radiotherapy.Results The median follow-up time was 40 months.The 3-year overall and relapse-free survival rates were 78.2% and 70.9%,respectively.Eighteen patients had tumor relapse.Fifty-three patients completed chemoradiotheray.Toxicities on grade 3 or above included gastrointestinal toxicity (28.1% ),eutropenia (21.8 % ) and alopecia ( 18.7% ).One patient died of hemorrhage of upper digestion tract.Conclusion Adjuvant radiotherapy with paclitaxol and cisplatin yielded satisfactory overall survival and disease-free survival in gastric cancer patients.The toxicity was manageable.Conformal radiotherapy seems to decrease the gastrointestinal toxicities compared to that occurred in the traditional radiotherapy.
