The impact on the endothelial cell function and renal blood flow through effective treatment for elderly patients with hypertension
10.3760/cma.j.issn.1008-6706.2010.08.008
- VernacularTitle:有效降血压治疗对老年高血压患者内皮细胞功能和肾血流的影响
- Author:
Qiuyan WANG
;
Lizhu BI
;
Jingcai XU
;
Xiaotang MA
- Publication Type:Journal Article
- Keywords:
Hypertension,Primary;
Endothelial cells;
Renal blood flow;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(8):1023-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact on the endothelial cell function and renal blood flow through effective treatment for elderly patients with hypertension. Methods 64 cases of elderly hypertensive patients over 70years old with effective treatment, according to pre-treatment blood pressure, were divided into two groups: hyptension level-2 group(30cases) and hypertension level-3 group(34cases), and 30 cases of elderly people with health physical examination during the same period were setlected as the control group. Endothelial cell function was detected, including the endothelin-1 (ET-1)、 nitrous oxide (NO), thromboxane B2 (TXB2)、 6-keto-prostaglandinF1α (6-K-PDGF1α) in plasma. Renal blood flow was explored by color doppler ultrasonic instrument ,involving peak velocity in systole(PSV) and lowest velocity in end-diastole(EDV) of renal arteries, segmental arteries and interlobar arteries.After indicators had reached the standard 1 month in the hypertension level-2 and hypertension leve1-3 patients with effective antihypertensive therapy, the difference of ET-1, NO, TXB2,6-k-PGF1o and PSV, EDV among the three groups were compared. Results The differences were statistically significant in ET-1, NO, TXB2,6-k-PGF1α, PSV and EDV before treatment among three groups (P ＜ 0.05). After blood pressure treated had reached the standard 1 month,indicators were no statistically meaningful difference among the three groups (P ＞ 0.05). Conclusion After effective clinical treatments, the endothelial cell function and renal blood flow of the elderly hypertensive patients can be improved. At the same time, to delay renal damage in elderly patients with hypertension provide a theoretical basis.
