Clinical observation of Pentoxifylline combined with mechanical ventilation in acute respiratory distress syndrome

VernacularTitle:己酮可可碱治疗急性呼吸窘迫综合征疗效观察
Author: Junda LIU ; Xiaoqin HUANG ; Linxi HUANG ; Honghui DING
Publication Type:Journal Article
Keywords: Respiration,artificial; Respiratory distress syndrome,adult; Pentoxifylline
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(8):1051-1052
CountryChina
Language:Chinese
Abstract: Objective To explorer the clinical effects of Pentoxifylline(PTX group) with mechanical ventilation in patients with acute respiratory distress syndrome(ARDS). Methods 64 patients with ARDS were randomized into a control group(n = 32 ,ARDS conventional treatment) and a PTX group(n = 32 ,PTX 50ml iv bid in addition to the conventional treatment). The patients were closely monitored with their curative effect, blood gas indexes and serum levels of TNF-α and IL-8 after the treatment. Results The PaO_2 and PaO_2/FiO_2 got significantly higher in the PTX group than in the control group on 3d and 7d (P ＜ 0.05). The serum levels of TNF-α and IL-8 and the mortality of ARDS were significantly decreased in the PTX group after the combined with Pentoxifylline (P ＜ 0.05 or P ＜0.01). Conclusion The treatment combined with the Pentoxifylline can effectively improve the Oxygenation and prognosis of ARDS patients by inhibiting the inflammatory responses.