The effect of telmisartan on APN,hs-CRP and TNF-α in hypertensive patients with unstable angina pectoris
10.3760/cma.j.issn.1008-6706.2010.08.026
- VernacularTitle:替米沙坦对高血压并不稳定型心绞痛患者血清脂联素、超敏C反应蛋白及肿瘤坏死因子表达的影响
- Author:
Yibin MEI
;
Fuyuan LI
;
Yangwei LI
;
Changsheng HU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Adiponectin;
C-reative protein;
Tumor necrosis factor-alpha;
Telmisartan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(8):1061-1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of telmisartan on the expression of APN,hs-CRP,TNF-α and the prognosis of hypertensive patients with unstable angina pectoris. Methods Totally 100 hypertensive patients with unstable angina pectoris were randomly divided into the telmisartan group(n =50) and the losartan group(n =50),each group with oral administration. The blood pressure controlled condition, APN, hs-CRP and TNF-α content changes and the occurrence of cardiovascular accident after treatment were observed in both two groups. Results In both groups, blood pressure returned to normal in 8 weeks,with no significant difference(P ＞ 0.05). After treatment,APN level in the telmisartan group increased faster than that in the losartan group(P ＜0.05) ,while the hs-CRP,TNF-αdecreased significantly(P ＜ 0.05). After 8 weeks, the occurrence of cardiovascular accident in the telmisartan and losartan groups was 10.0% (5/50) and 24. 5 % (12/49) respectively in the following 4 months (P ＜ 0.05). Conclusion Telmisartan has significant effect in regulating APN, hs-CRP, TNF-α expression in hypertensive patients with unstable angina pectoris, which is able to decrease the short-term occurrence of cardiovascular accident.
