Application of lamivudine in the treatment of chronic hepatitis B during pregnancy

VernacularTitle:拉米夫定在妊娠合并慢性乙型肝炎治疗中的应用
Author: Xiangrong LIN ; Yulin ZHAN
Publication Type:Journal Article
Keywords: Lamivudine; Pregnancy complications; Hepatitis B,chronic
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(10):1307-1308
CountryChina
Language:Chinese
Abstract: Objective To study the efficacy and safety of lamivudine in treatment of chronic hepatitis B with pregnancy. Methods 42 women with chronic hepatitis B in front of and during pregnancy were treated by lamivudine 100 mg once daily. The efficacy of antiviral therapy,mothers or their infants complications,the risk of perinatal transmission of HBV infection were observed. Results In lamivudine-treated group, serum HBV-DNA was not detected in 85.71%(36/42). Normalization of liver function was achieved in 88. 10% (37/42). Severe hepatitis B was not oc-cured,the rates of mothers or their infants complications and HBV perinatal transmission were also decreased obviously. Compared with control group,the differences were statistically significant(P <0. 05). Conclusions Lamivudine in the treatment of chronic hepatitis B during pregnancy was safe and effective,and conduced to improve the curative effect in treatment of chronic hepatitis B, and reduced mothers or their infants complications and HBV perinatal transmission.