Effect and safety of two treatment methods in patients with stable phase of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2010.06.001
- VernacularTitle:两种方法治疗稳定期慢性阻塞性肺病的疗效及安全性比较
- Author:
Weidong LIAO
;
Changqing LIN
;
Feng WU
- Publication Type:Journal Article
- Keywords:
Compound codeine phosphate syrup;
Ambroxol;
Chronic obstructive pulmonary disease,Stable phase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(6):721-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and safety of Compound codeine phosphate syrup with Ambroxol treatment in the stable phase of chronic obstructive pulmonary disease. Methods 100 patients with stable COPD were divided into Compound codeine phosphate syrup with Ambroxolt treatment group (Group A) 50 cases and Compound codeine phosphate syrup treatment group( Group B) 50 cases,drug were given for 3 ～ 7d. The symptom score and efficacy of two groups before treatment and after treatment were compared. Results The symptom score of cough,sputum volume,sputum viscosity ,wheeze,sleep after treatment 8th day were improved significantly ( χ2 = 3. 891 ,χ2 =3. 992, χ2 = 4. 198, χ2 = 3.981, χ2 = 3. 879, allP < 0. 05; Total effective rate of cough, sputum volume, sputum viscosity,wheeze in group A(92. 0% ,94. 0% ,90. 0% ,90. 0% ) higher than that in group B(80.0% ,86.0% ,80. 0%,78.0% ) ( χ2 = 3.991, χ2 = 4. 012, χ2 = 3. 998, χ2 = 3.971, allP < 0. 05); The adverse reactions of A、 B group were 12.0% and 14.0%(χ2 =1.971,P>0.05). Conclusion Compound codeine phosphate syrup with Ambroxol is an effective and safe antitussive in the stable phase of chronic obstructive pulmonary disease.
