Caloric restriction mimetics——A new territory in aging intervention
10.3760/cma.j.issn.1000-6699.2010.06.003
- VernacularTitle:能量限制拟似物——衰老干预研究的新领域
- Author:
Jiaoyue ZHANG
;
Lulu CHEN
- Publication Type:Journal Article
- Keywords:
CMoric restriction;
CMofic restriction mimetics;
Metformin;
Sirtuin
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(6):444-447
- CountryChina
- Language:Chinese
-
Abstract:
Caloric restriction(CR)remains the most robust one in all possible aging interventions,while the utility of it in humans would be difficult.CR mimeties(CRM)could mimic CR effects without changing calorie intake and have a promising prospect of application.CRM include glyeolysis inhibiter,insulin-like growth factorI,insulin sensitizer,sirtuins,PPAR agonists,and lipid-regulating drugs.
