The clinical effects of valsartan on the insulin resistance of type 2 diabetes patients with Ⅰ hypertension
10.3760/cma.j.issn.1008-6706.2010.09.013
- VernacularTitle:缬沙坦对2型糖尿病伴高血压患者胰岛素抵抗的临床疗效
- Author:
Weili WU
;
An ZHANG
;
Juanjuan CHEN
;
Yongjia LIU
- Publication Type:Journal Article
- Keywords:
Valsartan;
Diabetes mellitus,type 2;
Hypertension;
Insulin resistance
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(9):1177-1178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of valsartan on insulin resistance of type 2 diabetes in patients with Ⅰ hypertension.Methods Newly diagnosed 152 patients of type 2 diabetes with Ⅰ hypertension were randomly divided into treatment group and control group.The treatment group and control group undergone lifestyle changes( diet and adequate exercise) for two weeks.After that,the control group were given Diltiazem,while the treatment group were given valsartan,an angiotensin receptor blocker(ARB) drugs.Both groups were treated for 8 weeks.Fasting plasma glucose (FPG) and fasting plasma insulin (FINS) before and after treatment in both groups were determined.Homeostasis model assessment evaluation of insulin resistance index(HOMA-IR) and insulin sensitivity index (IAI) were carried out and compared between the two groups.Results After 8 weeks of treatment,HOMA-IR in the treatment group was significantly decreased compared with the control group ( P ＜ 0.01 ),while IAI was significantly increased( P ＜ 0.01 ).Conclusion Application of valsartan in type 2 diabetes mellitus with Ⅰ hypertension can significantly improve the level of insulin resistance.
