Analysis of the level of Serum 1,25-Dihydroxy Cholecalciferol in 30 children with Endogenous Hyperphosphatemia

VernacularTitle:内源性高磷血症患儿血清1,25-二羟基胆骨化醇水平变化
Author: Yuli ZHANG
Publication Type:Journal Article
Keywords: Hyperphosphatemia; 1,25 Dihydroxy Cholecalciferol
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(6):774-775
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of the level of 1,25-Dihydroxy Cholecalciferol in 30 cases of children with endogenous hyperphosphatemia. Methods Using fasting blood and OLPUMS AU400, determination of phosphorus by Phosphomolybdate ultraviolet France, determination of serum calcium by methyl thymol blue spectrophotometry (MTB) colorimetric, Determination of 1,25 (OH)2D3 levels in 30 cases of high-phosphorus blood group and 30 cases of normal serum phosphate group by Ydioimmunoassay. Results The phosphorus and calcium phosphate product in hyperphosphatemia group is significantly higher than the normal serum phosphate group. The difference is statistically significant. The calcium is slightly lower than the normal serum phosphate in hyperphosphatemia group, The difference is not significant ( P > 0. 05 ). The 1,25 (OH)2D3 of hyperphosphatemia group is significantly lower than the normal serum phosphate group. The difference ia statistically significant( P < 0. 01 ). Conclusion Hyperphosphatemia can inhibit the synthesis of 1,25 (OH)2D3.