Calcitriol pulse therapy combined with resin adsorption in treatment of severe secondary hyperparathyroidism

VernacularTitle:骨化三醇冲击联合树脂吸附治疗严重继发性甲状旁腺功能亢进症
Author: Changqing YU ; Hongli LIN ; Hong CHEN ; Hua XIE ; Ming FANG ; Hua SHENG
Publication Type:Journal Article
Keywords: Calcitriol; Hyperparathyroidism,secondary; Resin adsorption
From: Chinese Journal of Postgraduates of Medicine 2010;33(16):5-7
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of oral calcitriol pulse therapy combined with resin adsorption in treatment of severe secondary hyperparathyroidism.Methods Thirty-two hemodialysis patinents were randomly divided into three groups:oral calcitriol pulse therapy(CP group,12 cases),oral calcitriol pulse therapy combined with resin adsorption group(CP+RA group,10 cases),and resin adsorption group(RA group,10 cases).Serum immunoreactive parathyroid hormone(iPTH),albumin,urea,creatinine,hemoglobin levels were detected before treatment and 1,2,3 months after treatment respectively.Serum calcium and phosphorus levels were also detected every half a month.Results The clearance rate of resin adsorption Was decreased significantly every time(P<0.05).Serum iPTH in CP+RA group decreased significantly 2 months after treatment.Serum iPTH3 months after treatment in CP+RA group[(598.50 ±317.45)ng/L]was less than that in CP group[(1008.67±436.85)ng/L]and RA group[(1464.60±411.27)ns/L](P<0.05).Conclusion Oral calcitriol pulse therapy combined with resin adsorption can clear iPTH safely and effectively.