Melatonin fails to improve sleep in double-blind randomized placebo-controlled trial of institutionalized patients with alzheimer disease
10.3760/cma.j.issn.1008-6706.2010.10.018
- VernacularTitle:褪黑素对阿尔茨海默病患者睡眠障碍及昼夜节律失调的作用
- Author:
Wenfeng WANG
;
Lucheng ZHENG
;
Jiapeng PENG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Sleep diseasers,circadian rhythm;
Melatonin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(10):1329-1330
- CountryChina
- Language:Chinese
-
Abstract:
Objective Patients with Alzheimer dementia often display poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep. Methods Randomized, placebo controlled study was carried out in 41 patients with probable Alzheimer disease. Melatonin (8. 5 mg immediate release and 1. 5 mg sustained release) (n =24) or placebo (n = 17) administered at 22:00 P. M. for 10 consecutive nights. The protocol sleep was measured continuously using actigraphy. Results There were no significant effects of melatonin,compared with placebo,on sleep and circadian rhythms. Conclusion This study failed to find a beneficial effect of exogenous melatonin.
