Expression and clinical significance of Survivin and cyclooxygenase-2 in non-small cell lung cancer tissues
10.3760/cma.j.issn.1673-4904.2010.15.008
- VernacularTitle:非小细胞肺癌组织中Survivin和环氧合酶2的表达及其临床意义
- Author:
Zheng YI
;
Meiping ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Gene expression;
Cyclooxygenage 2:Survivin
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(15):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study relationship of expression of Survivin and cyclooxygenase(COX)-2 in the tissue of non-small cell lung cancer (NSCLC) with differentiation, lymph node metastasis and clinical stage. Method The expression of Survivin and COX-2 were detected by immunohistochemical SP staining in the specimens of 43 cases of NSCLC and 20 cases of para-cancerous lung tissue. Results The positive rate of Survivin and COX-2 was 67.4% (29/43) and 55.8% (24/43) respectively in NSCLC,was 0 respectively in the para-cancerous lung tissue. Compared with para-cancerous lung tissue,there was statistically significant difference(P< 0.01). Both Survivin and COX-2 had significantly higher expression in NSCLC with poor differentiation,lymph node metastasis and clinical stage of Ⅱ-Ⅲ than those with well differentiation,without metastasis and clinical stage of Ⅰ (P <0.05). Conclusion The expression of Survivin and COX-2 are high in NSCLC,they both have relationship with differentiation,lymph node metastasis and clinical stage of NSCLC.
