Relationship among serum uric acid,lipid and creatinine clearance rate of type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2010.12.001
- VernacularTitle:糖尿病肾病血尿酸与血脂及肌酐清除率的关系
- Author:
Xiaoqing ZHANG
;
Chengguo ZONG
;
Xuhua LUAN
;
Liming ZHAO
- Publication Type:Journal Article
- Keywords:
Uric acid;
Diabetic nephropathies;
Lipid;
Creatinine clearance rate
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(12):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of serum uric acid(SUA),lipid and creatinine(SCr) of type 2 diabetes mellitus(T2DM),and discuss the correlation between them and diabetic nephropathy(DN).Methods One hundred and two cases of T2DM patients were selected and divided into three groups based on the level of urine microalbumin(mAlb)/creatinine(Cr):30 cases of N-UAlb group(urine mAlb/Cr＜30μg/mg),41 cases of M-UAlb group(30μg/mg≤urine mAlb/Cr＜300μg/mg)and 31 cases of C-UAlb group(urine mAlb/Cr≥300 μg/mg),detected the SUA,SCr,HbA1c,fasting insulin(FINS),triglyeride(TG)and calculated the creatinine clearance rate(CCr).Selected 40 healthy subjects as control group.Results The SUA level in C-UAlb group[(369.3±181.2)μmol/L]was significantly higher than the other groups [(248.6±109.4)μmol/L in control group;(228.7±104.8)μmol/L in N-UAlb group;(296.5±121.4)μmol/L in M-UAIb group](P＜0.01 or＜0.05),and increased with increment of urine mAlb/Cr.In the whole study population,the Pearson correlation coefficient of SCr,CCr,TG and SUA were 0.369,-0.389.0.525,respectively(P＜0.01).Multiple regression analysis showed that SUA levels in T2DM patients were positively correlated with TG(P＜0.05),and were negatively correlated with CCr(P＜0.05).Conclusions TG and CCr are independent risk factors of SUA.CCr correlates with SUA better than SCr.Diabetic hyperuricemia might affect the process of occurrence and development of DN.There is need for prevention and treatment.
