Comparative evaluation of efficacy of tamsulosin versus tolterodine for the management of lower ureteral stones
10.3760/cma.j.issn.1673-4904.2010.12.009
- VernacularTitle:坦索罗辛和托特罗定对输尿管下段结石排石作用的比较
- Author:
Yunyan WANG
;
Jianquan HOU
;
Duangai WEN
;
Jun OUYANG
- Publication Type:Journal Article
- Keywords:
Ureteral calculi;
Tamsulosin;
Toherodine
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(12):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of tamsulosin and tolterodine for the adjunctive expulsive therapy in patients with lower ureteral stones.Methods A total of 160 patients with lower ureteral stones(4-10 mm)were included in the study.The patients were divided into 4 groups by block randomization.Group Ⅰ patients received tamsulosin 0.4 mg/d;group Ⅱpatients received tamsulosin 0.4 mg/d plus tolterodine 2 mg(twice a day);group Ⅲ patients received toherodine 2 mg(twice a day);and group Ⅳpatients served as controls.All patients were observed for 2 weeks.Remits The stone expulsion rate of group Ⅰ,Ⅱ,Ⅲ,Ⅳ was 76.9%(30/39),70.0%(28/40),46.2%(18/39)and 42.1%(16/38),respectively.The stone expulsion rate in group ⅠandⅡwas,higher than that in group Ⅲand Ⅳ(P＜0.05).The expulsion time of group Ⅰ,Ⅱ,Ⅲ,Ⅳ was(5.3±2.5),(6.4±2.2),(10.7±1.8),(12.8±3.4)d,respectively,with significant differences between group Ⅰ,Ⅱ andⅢ,Ⅳ,between groupⅢand Ⅳ(P＜0.05).Almost all of the patients tolerated the expulsive therapy and only 4 patients withdrew from treatment.No obvious side effect occurred.Conclusion The use of tamsulosin for the expulsion of lower ureteral stones is effective and safe;however,the use of tolteredine provides no additional advantages.
