Clinical study on intratympanic dexamethasone injection in treatment of sudden sensorineural hearing loss
10.3760/cma.j.issn.1673-4904.2010.15.007
- VernacularTitle:鼓室内注射地塞米松治疗突发性耳聋的临床观察
- Author:
Sheng ZHANG
;
Jiayun HUANG
- Publication Type:Journal Article
- Keywords:
Hearing loss,sensorineural;
Ear,middle;
Dexamethasone
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(15):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of intratympanic dexamethasone injection for patients with sudden sensorineural hearing loss (SSNHL). Methods Forty-four SSNHL cases (44 ears) which failed to respond to regular treatments were divided into two groups. The intratympanic injection group (24 eases) were injected dexamethasone 2.5 mg to the tympanic cavity every two days,4 times in all. The control group (20 eases) were treated with B1,B12 and triphosaden. Pure tone average (PTA) was tested before and 3 days after treatment. Results The total effective rate of intratympanic injection group was higher than that of control group [37.5%(9/24) vs 10.0%(2/20)] (P < 0.05). In intratympanic injection group, PTA of post-injection was significantly lower than the pre-injection[ (52.75±20.14) dB vs (70.26±20.76) dB ] (P < 0.05). PTA of post-injection in intratympanic injection group was significantly better than that in control group[(52.75±20.14) dB vs (63.55±19.36) dB](P< 0.05). Conclusion Intratympanic dexamethasone injection can be applied to SSNHL patients who failed to respond to systemic corticosteroid treatment and it can avoid the side effects brought on by high dose systemic corticosteroid treatment.
