Clinical observation of tacrolimus blood concentration after renal transplantation
10.3760/cma.j.issn.1008-6706.2010.10.005
- VernacularTitle:肾移植术后他克莫司血药浓度的临床观察
- Author:
Jianfeng ZHU
;
Yiyi ZHANG
;
Jiaying CHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Immunosuppressive agents;
Tacrolimus;
Plasma concentration
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(10):1305-1306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy and plasma concentrations of tacrolimus in renal transplant patients. Methods Kidney transplant patients were randomly divided into experimental group and control group. Control group was treated with cyclosporin A, experimental group was treated with tacrolimus. Clinical efficacy of two groups was compared,and plasma concentrations of tacrolimus the experimental group were tested at different periods. Results Compared with the control group,experimental group D-BILI and the concentration of T-BILI significantly lower,rate of acute rejection and infection significantly reduced,the differences were statistically significant (P <0.05) ;At the same time,in the experimental group,blood concentration of FK506 in patients at different periods after surgery were different. Conclusions . Tacrolimus was expected to develop ithe main immunosuppressant, its blood concentration factors of further research would be beneficial for to provide a reasonable regimen the clinical organ transplant patients.
