The diagnosis value of rheumatoid factor and anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis
10.3760/cma.j.issn.1008-6706.2010.10.007
- VernacularTitle:类风湿关节炎患者类风湿因子、抗环瓜氨酸多肽抗体检测的诊断价值
- Author:
Zhaojun GUO
;
Wei ZHOU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Rheumatoid factor;
Citrulline
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(10):1309-1310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of joint inspection of rheumatoid factor ( RF) and anti-cyclic citrullinated peptide antibodies(anti-CCP antibody) in rheumatoid arthritis( RA). Methods 125 patients with rheumatic disease were selected,including RA 78 cases,non-RA 47 cases. The quantitative ELISA to detect anti-CCP antibody, latex agglutination to test RF,and the data was analyzed. Results Anti-CCP antibody positive rate was 66. 7% ,RF was 74.4% Joint detection was 62.8% , single positive rate of joint detection was not statistically significant, but the specificity of joint detection was 98.6%,positive likelihood ratio was 29.2, significantly improved compared to individual testing;Sensitivity was 49.6%,negative predictive value was 54% ,significantly lower compared to test a-lone. Conclusion Combined detection was able to improve the specificity,positive likelihood ratio and reduce sensitivity , negative predictive value. It was more useful.
