Changes and clinical significane of plasma coagulation factor Ⅶ and antithrombin III in patients with acute myocardial infarction
10.3760/cma.j.issn.1008-6706.2010.10.010
- VernacularTitle:急性心肌梗死患者血浆凝血因子Ⅶ和抗凝血酶Ⅲ的变化及其意义
- Author:
Haiyan ZHANG
;
Huxiang ZHANG
;
Mingshan WANG
;
Zhongqiu LU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Factor VII;
Antithrombin Ⅲ
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(10):1315-1316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of plasma coagulation factor Ⅶ(FVII) and antithrombin III( AT-Ⅲ) in patients with acute myacardial infarction(AMI) . Methods The blood samples of 40 patients with AMI and 20 healthy volunteers were obtained through vein at the moment of admission. The plasma activated factors( FVIIag,FVI- la,FVII: C and AT-Ⅲ) were detected with different methods. Results Compared with control group,the plasina levels of FVIIag, FVIIa and the FVII: C in patients with AMI were significantly higher( P < 0.05, P < 0. 01) and especially in FVIIa(P <0.01) ,the AT-Ⅲ activity decreased significantly. Conclusion FVIIa and AT-III play important role in thrombosis of AMI,and the changes of their activities could predict the formation of acute cardiovascular event.
