Application of magnetic resonance spectroscopy in diagnosing DNS

VernacularTitle:氢质子磁共振波谱在一氧化碳中毒迟发性脑病诊断中的应用
Author: Zhongying FAN ; Hongbo ZHAN ; Youzhi ZHU ; Qingsong WANG ; Fucheng LUO
Publication Type:Journal Article
Keywords: Carbon monoxide poisoning; Spectrometry,X-Ray emission; Magnetic resonance imagining
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(9):1192-1194
CountryChina
Language:Chinese
Abstract: Objkctive To determine the potential ability of the area of each peak for the proton magnetic resonance spectroscopy(1 H-MRS) in the diagnosis of DNS(Delayed neuropsychological sequelae after carbon monoxide poisoning).Methods MRI and STEAM(stimulated-echo-acquisition mode)were performed in 38 DNS patients and 18 healthy volunteers.The area of the peak of each organic compound were obtained in each volume of interest.Results The data spectra abtained from patients shows NAA(881±76),Cho(2 352 ±86),β、γGlx(3 024 ± 187).Compared with the control group,theβ、γGlx ratio and Cho area increased,but the NAA ratio decreased.The area of NAA,Cho,β、γGlx between DNS and control group were compared,the results showed significant differences (P ＜0.05).In spectroscopy,the Lip evaluated peak in 0.9～1.40 ppm were detected.Conclusion 1H-MRS may do some contribution to the diagnosis of DNS.